Ciencia del HierroLab · 55 estudios

EL PLAN, CON 55ESTUDIOS

Las 6 reglas con las que se monta, cada una con su estudio, su autor y su año.

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La chuleta

La chuleta de la hipertrofia

Hipertrofia es que el músculo crezca. Esto es lo que dicen los estudios para conseguirlo.

55estudios en el banco
15citados en la chuleta
Regla 01 de 06

10 o más series por músculo a la semana

10+series por músculo y semanaCurrier et al., 2026

En cristianoCuenta series por músculo y semana, no ejercicios. Para crecer, de 10 para arriba.

Medicine and Science in Sports and Exercise2026

Revisión

American College of Sports Medicine Position Stand. Resistance Training Prescription for Muscle Function, Hypertrophy, and Physical Performance in Healthy Adults: An Overview of Reviews.

Currier BS, D'Souza AC, Singh MAF, Lowisz CV, Rawson ES, Schoenfeld BJ, et al.

… Muscle hypertrophy was enhanced by higher volumes (≥10 sets/wk) and eccentric overload. …
Currier et al., 2026PMID 41843416

La postura del ACSM, que junta 137 revisiones de estudios.

  • Cada serie semanal de más se asoció con un 0,37 % más de ganancia.Schoenfeld et al., 2017
  • Si vas justo de tiempo, el mínimo que recomiendan es 4.Iversen et al., 2021
Regla 02 de 06

Cada músculo, 2 veces por semana

2veces por semana, como mínimoSchoenfeld et al., 2016

En cristianoMejor dos días de pierna que uno eterno: reparte las series.

Sports Medicine2016

Metaanálisis

Effects of Resistance Training Frequency on Measures of Muscle Hypertrophy: A Systematic Review and Meta-Analysis.

Schoenfeld BJ, Ogborn D, Krieger JW

… It can therefore be inferred that the major muscle groups should be trained at least twice a week to maximize muscle growth; whether training a muscle group three times per week is superior to a twice-per-week protocol remains to be …
Schoenfeld et al., 2016PMID 27102172

Un metaanálisis: junta los datos de muchos estudios.

  • Con las mismas series, la frecuencia da igual: lo dice un metaanálisis de 25 estudios.Schoenfeld et al., 2019
  • Rutina dividida o cuerpo entero, lo mismo: 14 estudios con 392 personas.Ramos-Campo et al., 2024
Regla 03 de 06

Acaba cada serie cerca del fallo

15estudios: llegar al fallo no da más músculoRefalo et al., 2023

En cristianoQue las últimas repeticiones cuesten de verdad. Reventar cada serie no suma.

Sports Medicine2024

Metaanálisis

Exploring the Dose-Response Relationship Between Estimated Resistance Training Proximity to Failure, Strength Gain, and Muscle Hypertrophy: A Series of Meta-Regressions.

Robinson ZP, Pelland JC, Remmert JF, Refalo MC, Jukic I, Steele J, et al.

… Strength gains were similar across a wide range of RIR, while muscle hypertrophy improves as sets are terminated closer to failure. …
Robinson et al., 2024PMID 38970765

El fallo: cuando no sale ni una repetición más.

  • RIR son las repeticiones que te quedaban en la recámara: con 0, llegaste al fallo.Zourdos et al., 2016
Regla 04 de 06

De 6 a 15 repeticiones

6–15repeticiones por serieIversen et al., 2021

En cristianoCon poco peso también vale, si llegas cerca del fallo.

Sports Medicine2021

Revisión

No Time to Lift? Designing Time-Efficient Training Programs for Strength and Hypertrophy: A Narrative Review.

Iversen VM, Norum M, Schoenfeld BJ, Fimland MS

… Weekly training volume is more important than training frequency and we recommend performing a minimum of 4 weekly sets per muscle group using a 6-15 RM loading range (15-40 repetitions can be used if training is performed to volitional failure). …
Iversen et al., 2021PMID 34125411

Una revisión de cómo entrenar con poco tiempo.

  • Con cargas ligeras, de 15 a 40 repeticiones, si llegas al fallo.Iversen et al., 2021
  • El músculo crece con cargas muy distintas: no hay un rango mágico.Schoenfeld et al., 2021
Regla 05 de 06

Descansa más de 1 minuto

3minutos: más fuerza y más músculo que con 1Schoenfeld et al., 2016

En cristianoEn hombres entrenados, descansar 3 minutos dio más fuerza y más músculo que descansar 1, en 8 semanas.

Journal of Strength and Conditioning Research2016

Ensayo

Longer Interset Rest Periods Enhance Muscle Strength and Hypertrophy in Resistance-Trained Men.

Schoenfeld BJ, Pope ZK, Benik FM, Hester GM, Sellers J, Nooner JL, et al.

… This study provides evidence that longer rest periods promote greater increases in muscle strength and hypertrophy in young resistance-trained men.
Schoenfeld et al., 2016PMID 26605807

Un ensayo: un grupo descansaba 1 minuto y el otro, 3.

  • Una revisión de 6 estudios apunta lo mismo: en gente entrenada, más de 60 segundos podría dar más músculo.Grgic et al., 2017
Regla 06 de 06

Máquina o peso libre: el que te guste

13estudios: el mismo músculo con máquinas que con peso libreHaugen et al., 2023

En cristianoEl músculo no sabe qué aparato usas. Elige el que te deje entrenar a gusto.

BMC Sports Science, Medicine & Rehabilitation2023

Estudio

Effect of free-weight vs. machine-based strength training on maximal strength, hypertrophy and jump performance - a systematic review and meta-analysis.

Haugen ME, Vårvik FT, Larsen S, Haugen AS, van den Tillaar R, Bjørnsen T

… Conclusion No differences were detected in the direct comparison of strength, jump performance and muscle hypertrophy. …
Haugen et al., 2023PMID 37582807

Un metaanálisis con 1016 personas.

  • En principiantes, básicos o aislados, igual: con jalón al pecho el bíceps creció un 6,10 %, y con curl, un 5,83 %.Gentil et al., 2015
  • En el tren superior, busca la posición en la que el músculo se estira: con todo el recorrido o con parciales ahí.Wolf et al., 2025
La chuleta · 1080 × 1920

Guárdala

Mantén pulsada la imagen para guardarla. Súbela a tu historia y menciona a @cienciadelhierro.

La chuleta de la hipertrofia: Series por músculo y semana, 10 o más; Veces por semana cada músculo, 2 o más; Esfuerzo, Cerca del fallo; Repeticiones por serie, 6–15; Descanso entre series, Más de 1 min; Aparato, El que te guste.
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Los 55 estudios del banco · con su PubMed
  1. American College of Sports Medicine Position Stand. Resistance Training Prescription for Muscle Function, Hypertrophy, and Physical Performance in Healthy Adults: An Overview of Reviews.Currier BS, D'Souza AC, Singh MAF, et al. · Medicine and Science in Sports and Exercise · 2026 · PMID 41843416
  2. The Resistance Training Dose Response: Meta-Regressions Exploring the Effects of Weekly Volume and Frequency on Muscle Hypertrophy and Strength Gains.Pelland JC, Remmert JF, Robinson ZP, et al. · Sports Medicine · 2026 · PMID 41343037
  3. Effects of High Intensity Circuit Versus Traditional Strength Training on Physiological Responses in Trained Women.Carpenter SL, Helms ER, Pendakur RC, et al. · European Journal of Sport Science · 2025 · PMID 40323711
  4. Quantification of weekly strength-training volume per muscle group in competitive physique athletes.da Silveira TB, de Almeida GPL, Junior NC, et al. · Frontiers in Sports and Active Living · 2025 · PMID 40809103
  5. The effects, mechanisms, and influencing factors of concurrent strength and endurance training with different sequences: a semi-systematic review.Feng Z, Ying W, Jun W · Frontiers in Sports and Active Living · 2025 · PMID 41669271
  6. Autoregulated resistance training for maximal strength enhancement: A systematic review and network meta-analysis.Zijing Huang, Sun J, Li D, et al. · Journal of Exercise Science and Fitness · 2025 · PMID 40791980
  7. Lengthened partial repetitions elicit similar muscular adaptations as full range of motion repetitions during resistance training in trained individuals.Wolf M, Androulakis Korakakis P, Piñero A, et al. · PeerJ · 2025 · PMID 39959841
  8. Minimalist Training: Is Lower Dosage or Intensity Resistance Training Effective to Improve Physical Fitness? A Narrative Review.Behm DG, Granacher U, Warneke K, et al. · Sports Medicine · 2024 · PMID 37924459
  9. Efficacy of Split Versus Full-Body Resistance Training on Strength and Muscle Growth: A Systematic Review With Meta-Analysis.Ramos-Campo DJ, Benito-Peinado PJ, Andreu-Caravaca L, et al. · Journal of Strength and Conditioning Research · 2024 · PMID 38595233
  10. Exploring the Dose-Response Relationship Between Estimated Resistance Training Proximity to Failure, Strength Gain, and Muscle Hypertrophy: A Series of Meta-Regressions.Robinson ZP, Pelland JC, Remmert JF, et al. · Sports Medicine · 2024 · PMID 38970765
  11. Optimizing concurrent training programs: A review on factors that enhance muscle strength.Wang T, Bo S · Medicine · 2024 · PMID 39969307
  12. Integrating Deloading into Strength and Physique Sports Training Programmes: An International Delphi Consensus Approach.Bell L, Strafford BW, Coleman M, et al. · Sports Medicine - Open · 2023 · PMID 37730925
  13. Effect of High-Intensity Interval Training vs. Moderate-Intensity Continuous Training on Fat Loss and Cardiorespiratory Fitness in the Young and Middle-Aged a Systematic Review and Meta-Analysis.Guo Z, Li M, Cai J, et al. · International Journal of Environmental Research and Public Health · 2023 · PMID 36981649
  14. Effect of free-weight vs. machine-based strength training on maximal strength, hypertrophy and jump performance - a systematic review and meta-analysis.Haugen ME, Vårvik FT, Larsen S, et al. · BMC Sports Science, Medicine & Rehabilitation · 2023 · PMID 37582807
  15. Effect of Small and Large Energy Surpluses on Strength, Muscle, and Skinfold Thickness in Resistance-Trained Individuals: A Parallel Groups Design.Helms ER, Spence AJ, Sousa C, et al. · Sports Medicine - Open · 2023 · PMID 37914977
  16. High-intensity interval training is not superior to continuous aerobic training in reducing body fat: A systematic review and meta-analysis of randomized clinical trials.Kramer AM, Martins JB, de Oliveira PC, et al. · Journal of Exercise Science and Fitness · 2023 · PMID 37927356
  17. Influence of Resistance Training Proximity-to-Failure on Skeletal Muscle Hypertrophy: A Systematic Review with Meta-analysis.Refalo MC, Helms ER, Trexler ET, et al. · Sports Medicine · 2023 · PMID 36334240
  18. Resistance training volume does not influence lean mass preservation during energy restriction in trained males.Roth C, Schwiete C, Happ K, et al. · Scandinavian Journal of Medicine & Science in Sports · 2023 · PMID 36114738
  19. Effects of progressive body-weight versus barbell back squat training on strength, hypertrophy and body fat among sedentary young women.Wei W, Zhu J, Ren S, et al. · Scientific Reports · 2023 · PMID 37598268
  20. Effects of Periodization on Strength and Muscle Hypertrophy in Volume-Equated Resistance Training Programs: A Systematic Review and Meta-analysis.Moesgaard L, Beck MM, Christiansen L, et al. · Sports Medicine · 2022 · PMID 35044672
  21. A randomized trial on the efficacy of split-body versus full-body resistance training in non-resistance trained women.Pedersen H, Fimland MS, Schoenfeld BJ, et al. · BMC Sports Science, Medicine & Rehabilitation · 2022 · PMID 35568897
  22. Lean mass sparing in resistance-trained athletes during caloric restriction: the role of resistance training volume.Roth C, Schoenfeld BJ, Behringer M · European Journal of Applied Physiology · 2022 · PMID 35146569
  23. Split or full-body workout routine: which is best to increase muscle strength and hypertrophy?Evangelista AL, Braz TV, La Scala Teixeira CV, et al. · Einstein · 2021 · PMID 34468591
  24. Equal-Volume Strength Training With Different Training Frequencies Induces Similar Muscle Hypertrophy and Strength Improvement in Trained Participants.Hamarsland H, Moen H, Skaar OJ, et al. · Frontiers in Physiology · 2021 · PMID 35069251
  25. No Time to Lift? Designing Time-Efficient Training Programs for Strength and Hypertrophy: A Narrative Review.Iversen VM, Norum M, Schoenfeld BJ, et al. · Sports Medicine · 2021 · PMID 34125411
  26. The effect of acute sleep deprivation on skeletal muscle protein synthesis and the hormonal environment.Lamon S, Morabito A, Arentson-Lantz E, et al. · Physiological Reports · 2021 · PMID 33400856
  27. Effects of Resistance Circuit-Based Training on Body Composition, Strength and Cardiorespiratory Fitness: A Systematic Review and Meta-Analysis.Ramos-Campo DJ, Andreu Caravaca L, Martínez-Rodríguez A, et al. · Biology · 2021 · PMID 33924785
  28. Loading Recommendations for Muscle Strength, Hypertrophy, and Local Endurance: A Re-Examination of the Repetition Continuum.Schoenfeld BJ, Grgic J, Van Every DW, et al. · Sports · 2021 · PMID 33671664
  29. Maintaining Physical Performance: The Minimal Dose of Exercise Needed to Preserve Endurance and Strength Over Time.Spiering BA, Mujika I, Sharp MA, et al. · Journal of Strength and Conditioning Research · 2021 · PMID 33629972
  30. Using Machines or Free Weights for Resistance Training in Novice Males? A Randomized Parallel Trial.Aerenhouts D, D'Hondt E · International Journal of Environmental Research and Public Health · 2020 · PMID 33114782
  31. Sex Differences in Resistance Training: A Systematic Review and Meta-Analysis.Roberts BM, Nuckols G, Krieger JW · Journal of Strength and Conditioning Research · 2020 · PMID 32218059
  32. Resistance Training for Older Adults: Position Statement From the National Strength and Conditioning Association.Fragala MS, Cadore EL, Dorgo S, et al. · Journal of Strength and Conditioning Research · 2019 · PMID 31343601
  33. Nutrition Recommendations for Bodybuilders in the Off-Season: A Narrative Review.Iraki J, Fitschen P, Espinar S, et al. · Sports · 2019 · PMID 31247944
  34. Resistance Training Volume Enhances Muscle Hypertrophy but Not Strength in Trained Men.Schoenfeld BJ, Contreras B, Krieger J, et al. · Medicine and Science in Sports and Exercise · 2019 · PMID 30153194
  35. How many times per week should a muscle be trained to maximize muscle hypertrophy? A systematic review and meta-analysis of studies examining the effects of resistance training frequency.Schoenfeld BJ, Grgic J, Krieger J · Journal of Sports Sciences · 2019 · PMID 30558493
  36. Sex Differences in the Temporal Recovery of Neuromuscular Function Following Resistance Training in Resistance Trained Men and Women 18 to 35 Years.Davies RW, Carson BP, Jakeman PM · Frontiers in Physiology · 2018 · PMID 30405436
  37. Effect of Resistance Training Frequency on Gains in Muscular Strength: A Systematic Review and Meta-Analysis.Grgic J, Schoenfeld BJ, Davies TB, et al. · Sports Medicine · 2018 · PMID 29470825
  38. Effect of Progressive Calisthenic Push-up Training on Muscle Strength and Thickness.Kotarsky CJ, Christensen BK, Miller JS, et al. · Journal of Strength and Conditioning Research · 2018 · PMID 29466268
  39. The effects of short versus long inter-set rest intervals in resistance training on measures of muscle hypertrophy: A systematic review.Grgic J, Lazinica B, Mikulic P, et al. · European Journal of Sport Science · 2017 · PMID 28641044
  40. Effects of linear and daily undulating periodized resistance training programs on measures of muscle hypertrophy: a systematic review and meta-analysis.Grgic J, Mikulic P, Podnar H, et al. · PeerJ · 2017 · PMID 28848690
  41. The Effect of Weekly Set Volume on Strength Gain: A Meta-Analysis.Ralston GW, Kilgore L, Wyatt FB, et al. · Sports Medicine · 2017 · PMID 28755103
  42. Dose-response relationship between weekly resistance training volume and increases in muscle mass: A systematic review and meta-analysis.Schoenfeld BJ, Ogborn D, Krieger JW · Journal of Sports Sciences · 2017 · PMID 27433992
  43. Resistance training-induced changes in integrated myofibrillar protein synthesis are related to hypertrophy only after attenuation of muscle damage.Damas F, Phillips SM, Libardi CA, et al. · The Journal of Physiology · 2016 · PMID 27219125
  44. Application of the Repetitions in Reserve-Based Rating of Perceived Exertion Scale for Resistance Training.Helms ER, Cronin J, Storey A, et al. · Strength and Conditioning Journal · 2016 · PMID 27531969
  45. Effects of Resistance Training Frequency on Measures of Muscle Hypertrophy: A Systematic Review and Meta-Analysis.Schoenfeld BJ, Ogborn D, Krieger JW · Sports Medicine · 2016 · PMID 27102172
  46. Longer Interset Rest Periods Enhance Muscle Strength and Hypertrophy in Resistance-Trained Men.Schoenfeld BJ, Pope ZK, Benik FM, et al. · Journal of Strength and Conditioning Research · 2016 · PMID 26605807
  47. Novel Resistance Training-Specific Rating of Perceived Exertion Scale Measuring Repetitions in Reserve.Zourdos MC, Klemp A, Dolan C, et al. · Journal of Strength and Conditioning Research · 2016 · PMID 26049792
  48. Single vs. Multi-Joint Resistance Exercises: Effects on Muscle Strength and Hypertrophy.Gentil P, Soares S, Bottaro M · Asian Journal of Sports Medicine · 2015 · PMID 26446291
  49. Changes in exercises are more effective than in loading schemes to improve muscle strength.Fonseca RM, Roschel H, Tricoli V, et al. · Journal of Strength and Conditioning Research · 2014 · PMID 24832974
  50. Chronic psychological stress impairs recovery of muscular function and somatic sensations over a 96-hour period.Stults-Kolehmainen MA, Bartholomew JB, Sinha R · Journal of Strength and Conditioning Research · 2014 · PMID 24343323
  51. Single vs. multiple sets of resistance exercise for muscle hypertrophy: a meta-analysis.Krieger JW · Journal of Strength and Conditioning Research · 2010 · PMID 20300012
  52. American College of Sports Medicine position stand. Progression models in resistance training for healthy adults.American College of Sports Medicine · Medicine and Science in Sports and Exercise · 2009 · PMID 19204579
  53. Strength gains after resistance training: the effect of stressful, negative life events.Bartholomew JB, Stults-Kolehmainen MA, Elrod CC, et al. · Journal of Strength and Conditioning Research · 2008 · PMID 18545186
  54. A meta-analysis to determine the dose response for strength development.Rhea MR, Alvar BA, Burkett LN, et al. · Medicine and Science in Sports and Exercise · 2003 · PMID 12618576
  55. The time course for elevated muscle protein synthesis following heavy resistance exercise.MacDougall JD, Gibala MJ, Tarnopolsky MA, et al. · Canadian Journal of Applied Physiology = Revue Canadienne de Physiologie Appliquee · 1995 · PMID 8563679